284785

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid

98%

• 동의어(들): Naproxen, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
• Linear Formula: CH₃OC₁₀H₆CH(CH₃)CO₂H
• CAS Number: 22204-53-1
• Molecular Weight: 230.26
• Beilstein: 3591068
• EC Number: 244-838-7
• MDL number: MFCD00010500
• UNSPSC 코드: 12352005
• PubChem Substance ID: 24857178
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: 98%
• 광학 활성: [α]25/D +66°, c = 1 in chloroform
• mp: 152-154 °C (lit.)
• 작용기: carboxylic acid
• SMILES string: COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O
• InChI: 1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
• InChI key: CMWTZPSULFXXJA-VIFPVBQESA-N
• 유전자 정보: human ... MAPK14(1432) , PTGS1(5742) , PTGS2(5743) ; rat ... Alox5(25290) , Ptgs1(24693)

설명

일반 설명

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid is a nonsteroidal anti-inflammatory molecule (NSAID). The (S)-enantiomer is 30 times more active than the (R)-enantiomer.[1][2]

애플리케이션

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid can be used as a chiral ligand in the synthesis of organotin (IV) carboxylate metal complexes.[3][4]

생화학적/생리학적 작용

Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335,H361fd,H411
• 예방조치 성명서: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3