I4883

Ibuprofen

≥98% (GC), powder, COX inhibitor

• 동의어(들): 2-(4-Isobutylphenyl)propanoic acid, Brufen, Motrin, Rebugen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid
• 실험식(Hill 표기법): C₁₃H₁₈O₂
• CAS Number: 15687-27-1
• Molecular Weight: 206.28
• EC Number: 239-784-6
• MDL number: MFCD00010393
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277715
• NACRES: NA.77

속성

• product name: Ibuprofen, ≥98% (GC)
• 생물학적 소스: synthetic (organic)
• 분석: ≥98% (GC)
• 형태: powder
• mp: 77-78 °C
• solubility: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• SMILES string: CC(C)Cc1ccc(cc1)C(C)C(O)=O
• InChI: 1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
• InChI key: HEFNNWSXXWATRW-UHFFFAOYSA-N
• 유전자 정보: human ... ALB(213) , ALOX5(240) , CYP1A2(1544) , CYP2C9(1559) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) ; rat ... Alox5(25290) , Ptgs1(24693)

설명

일반 설명

Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.

애플리케이션

Ibuprofen has been used:

• to study its vascular and pulmonary effects on neonatal lung development
• to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines
• in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties

생화학적/생리학적 작용

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves