모든 사진(1)
About This Item
실험식(Hill 표기법):
C12H15N
CAS Number:
Molecular Weight:
173.25
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
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추천 제품
분석
97%
양식
solid
약물 제어
regulated under CDSA - not available from Sigma-Aldrich Canada
bp
128-132 °C/12 mmHg (lit.)
작용기
phenyl
SMILES string
CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
InChI key
PLRACCBDVIHHLZ-UHFFFAOYSA-N
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생화학적/생리학적 작용
Dopaminergic neurotoxin.
경고
Reportedly causes a severe and irreversible Parkinsonism condition in humans and monkeys. New Engl. J. Med. 1983, 309, 310. Science 1983, 219, 979. ibid. 1984, 224, 1083, 1451. ibid. 1984, 225, 529. J. Med. Chem. 1985, 28, 997.
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 1
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
235.4 °F - closed cup
Flash Point (°C)
113 °C - closed cup
가장 최신 버전 중 하나를 선택하세요:
Gejuan Zhang et al.
Life sciences, 232, 116600-116600 (2019-06-30)
Neuroinflammation is one of the significant neuropathological conditions in Parkinson's disease (PD) which is due to microglial and astrocytes activation leads to progressive dopaminergic neuronal loss. To date, Current PD drugs offers only symptomatic relief with adverse effects and lack
Hideaki Matsui et al.
Journal of neural transmission (Vienna, Austria : 1996), 125(1), 25-33 (2017-08-05)
Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a
Yuanyuan Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(1-2), 18-26 (2016-11-15)
Development of effective therapeutic drugs for Parkinson's disease is in great need. During the progression of Parkinson's disease, Rho-associated protein kinase 2 (ROCK2) is activated to promote neurodegeneration. Hydrogen sulfide (H2S) has a neuroprotective effect during the neural injury of
David I Finkelstein et al.
Acta neuropathologica communications, 5(1), 53-53 (2017-07-01)
Elevated iron in the SNpc may play a key role in Parkinson's disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal models, and one candidate, deferirpone, has shown efficacy recently in a phase two clinical trial.
Yan Liu et al.
Aging, 11(14), 5008-5034 (2019-07-18)
Parkinson's disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such as cognitive impairment, and malfunction of gamma-aminobutyric acid (GABA) mediated inhibitory transmission plays an important role in PD pathogenesis. The ginsenoside Rb1 molecule, a
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