M0896
MPTP Hydrochloride
≥98% (AgNO3), powder, dopaminergic neurotoxin
동의어(들):
MPTP HCl, Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride, MPTP hydrochloride
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C12H15N · HCl
CAS Number:
Molecular Weight:
209.72
Beilstein:
3707312
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, powder
양식
powder
Quality Level
drug control
kontrollierte Droge in Deutschland
색상
white to off-white
SMILES string
Cl[H].CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChI key
KOWJANGMTAZWDT-UHFFFAOYSA-N
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일반 설명
MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.
애플리케이션
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models:
- to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system
- to study the behavioral impairments correlated to neurochemical deficits
- to study the effects of treadmill exercise on neuroprotection and neuroinflammation
MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.
생화학적/생리학적 작용
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.
Dopaminergic neurotoxin.
경고
Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 1
표적 기관
Nervous system
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Hypoxia inducible factor-1? regulates microglial innate immune memory and the pathology of Parkinson?s disease
Dong, et al.
Journal of Neuroinflammation (2024)
Ibrahim Kaya et al.
NPJ Parkinson's disease, 9(1), 118-118 (2023-07-27)
Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson's disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non-human primates. However, the complete molecular pathology underlying MPTP-induced
Isoquinuclidines: a review of chemical and pharmacological properties
Khan MOF, et al.
Studies in Natural Products Chemistry, 34, 753-787 (2008)
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Tillerson JL, et al.
Experimental neurology (2002)
Yuliya V Medvedeva et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(4), 1105-1114 (2009-01-30)
Despite considerable evidence for contributions of both Zn(2+) and Ca(2+) in ischemic brain damage, the relative importance of each cation to very early events in injury cascades is not well known. We examined Ca(2+) and Zn(2+) dynamics in hippocampal slices
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