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  • Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats.

Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging (2013-08-21)
G U Mohangi, B Rothman, A W van Zyl, N Duneas
要旨

Demineralised bone matrix (DBM) is an allograft material widely used as a bone filler and bone graft substitute. DBM contains bone morphogenetic proteins (BMPs), which induce and regulate bone formation during embryogenesis and in postnatal life. To investigate the osteoinductivity of DBM augmented with xenogeneic BMP-complex at different doses. Rat DBM was augmented with BMP-complex purified from porcine diaphyseal bone. Dorsal subcutaneous implantation of 25 mg rat allogeneic DBM augmented with 0, 3, 6 and 12 mg BMP-complex per gram of DBM resulted in dose dependant up-regulation of bone formation on day 21, as scored histologically and biochemically. Allogeneic DBM can be augmented with xenogeneically sourced BMP-complex to improve DBM performance in vivo. This work demonstrates the potential of BMP-complex augmented DBM to induce new bone formation with improved parameters of bone formation.

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製品内容

Sigma-Aldrich
アルカリホスファターゼ from bovine intestinal mucosa, lyophilized powder, ≥10 DEA units/mg solid
Sigma-Aldrich
アルカリホスファターゼ from bovine intestinal mucosa, BioUltra, ≥5,700 DEA units/mg protein
Sigma-Aldrich
アルカリホスファターゼ from bovine intestinal mucosa, buffered aqueous solution, ≥2,000 DEA units/mg protein
Sigma-Aldrich
アルカリホスファターゼ 大腸菌由来, lyophilized powder, 30-60 units/mg protein (in glycine buffer)
Sigma-Aldrich
アルカリホスファターゼ from bovine intestinal mucosa, buffered aqueous glycerol solution, ≥4,000 DEA units/mg protein
Sigma-Aldrich
アルカリホスファターゼ from bovine intestinal mucosa, ≥5,500 DEA units/mg protein
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Phosphatase, Alkaline from porcine kidney, lyophilized powder, ≥100 DEA units/mg protein
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アルカリホスファターゼ 大腸菌由来, ammonium sulfate suspension, 30-90 units/mg protein (modified Warburg-Christian, in glycine buffer)
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アルカリホスファターゼ 大腸菌由来, buffered aqueous glycerol solution, 20-50 units/mg protein (in glycine buffer)
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アルカリホスファターゼ エビ由来, ≥900 DEA units/mL, buffered aqueous glycerol solution, recombinant, expressed in proprietary host
Sigma-Aldrich
アルカリホスファターゼ ウシ, recombinant, expressed in Pichia pastoris, ≥4000 units/mg protein