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product name
Astec®CHIROBIOTIC®V Chiral HPLC Column（キラルHPLCカラム）, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
物質
stainless steel column
認証
suitable for USP L88
詳細
HPLC Column
製品種目
Astec®
包装
pkg of 1 ea
メーカー／製品名
Astec®
パラメーター
0-45 °C temperature
241 bar pressure (3500 psi)
テクニック
HPLC: suitable
LC/MS: suitable
L × 内径
15 cm × 2.1 mm
マトリックス
High-purity silica gel particle platform
fully porous particle
マトリックス活性基
vancomycin phase
粒径
5 μm
ポアサイズ
100 Å
operating pH range
3.5-7.0
分離法
chiral
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詳細
Astec CHIROBIOTIC® CSPs (chiral stationary phases) interact with ionisable, polar and neutral analytes through multiple molecular interactions. This property makes it widely versatile, thereby making it applicable in a variety of mobile phases. Another feature is the presence of ionic interactions, allowing them to be used reversed-phase and polar ionic modes for sensitive LC-MS operation. CHIROBIOTIC® V is based on bonding Vancomycin which contains 18 chiral centers surrounding three cavities or pockets. These cavities are surrounded with five aromatic rings. Hydrogen acceptor and donor sites are present very near to the ring structures. The CHIROBIOTIC® V is similar to glycoprotein phase′s selectivity wise, with its exception of exhibiting high sample capacity and being stable from 0-100% organic modifier.
中性分子、アミド、酸、エステル、およびアミンは、これらのバンコマイシンをベースとするCSPに高いエナンチオ選択性を示します。極性を持つイオン性モードの CHIROBIOTIC®V上で、多くの種類の第二級および第三級アミンが分離されました。CHIROBIOTIC® Vはタンパク質ベースの静置相が持つ分離特性の多くを示しますが、安定性が著しく高く、はるかに大きな試料容量を持っています。他のキラル静置相で分離された報告がないキラル検体のいくつかが分割されました。CHIROBIOTIC® VとV2は結合の化学的性質と支持粒子の細孔径が異なるため、選択性と調製容量に違いがあります。
- 結合相:バンコマイシン
- 動作するpH範囲:3.5～7.0
- 粒径:5、10、または16 μm
- 細孔径:100 Å (CHIROBIOTIC® V) または200 Å (CHIROBIOTIC® V2)
アプリケーション
Chirobiotic V HPLC column may be used for separating the enantiomers of citalopram and its two N-demethylated metabolites, and of the internal standard, alprenolol, in human plasma.
法的情報
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Choose from one of the most recent versions:
M Kosel et al.
Journal of chromatography. B, Biomedical sciences and applications, 719(1-2), 234-238 (1998-12-30)
A procedure using a chirobiotic V column is presented which allows separation of the enantiomers of citalopram and its two N-demethylated metabolites, and of the internal standard, alprenolol, in human plasma. Citalopram, demethylcitalopram and didemethylcitalopram, as well as the internal
Ana R Ribeiro et al.
Chemosphere, 95, 589-596 (2013-11-05)
Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate
Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma
Sultan, Maha A., et al.
Arabian Journal of Chemistry, 3 (3), 147-153 (2010)
Hisham Hashem et al.
Journal of chromatography. A, 1218(38), 6727-6731 (2011-08-23)
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the
Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series
Rao, R. Nageswara, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (21), 1911-1916 (2011)
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