U8881

UCL 1684 ditrifluoroacetate hydrate

• 別名: 6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
• 化学式: (C₃₄H₃₀N₄)²⁺ · (C₂F₃O₂^-)₂ · xH₂O
• CAS番号: 201147-19-5
• 分子量: 720.66 (anhydrous basis)
• UNSPSCコード: 12352200
• PubChem Substance ID: 24900684
• NACRES: NA.77

特性

• 色: white to off-white
• 溶解性: DMSO: 10 mg/mL
• SMILES記法: [H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
• InChI: 1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
• InChI Key: YROHEYZVNZITJN-DDVHGCDCSA-N

詳細

アプリケーション

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries.

生物化学的／生理学的作用

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.

特徴および利点

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

調製ノート

UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)