T8703

T0070907

≥98% (HPLC)

• 別名: 2-クロロ-5-ニトロ-N-4-ピリジニル-ベンズアミド, ベンズアミド、2-クロロ-5-ニトロ-N-4-ピリジニル-
• 実験式（ヒル表記法）: C₁₂H₈ClN₃O₃
• CAS番号: 313516-66-4
• 分子量: 277.66
• MDL番号: MFCD00121849
• UNSPSCコード: 12352203
• PubChem Substance ID: 329826884
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white
• 溶解性: DMSO: >10 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2
• InChI: 1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
• InChI Key: FRPJSHKMZHWJBE-UHFFFAOYSA-N

詳細

詳細

T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.

アプリケーション

T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.

T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection.

生物化学的／生理学的作用

T0070907は構造と活性がPPAR-γアンタゴニストGW9662にきわめて類似しています。T0070907は、他のどのサブタイプよりもPPAR-γに対して強力に作用し、高い選択性を示しますが(約800倍)、GW9662はPPAR-αアゴニスト活性を示すことが報告されています。

特徴および利点

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

調製ノート

T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves