T2815

トランスフォーミング増殖因子-β2 ヒト

≥97% (electrophoresis), recombinant, expressed in NSO cells, powder, suitable for cell culture

• 別名: hTGF-β2, TGF-β2
• MDL番号: MFCD00163957
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 製品名: トランスフォーミング増殖因子-β2 ヒト, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture
• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in NSO cells
• アッセイ: ≥97% (electrophoresis)
• フォーム: powder
• 有効性: 0.04 ng/mL ED₅₀
• 品質: endotoxin tested
• 分子量: 25 kDa
• 包装: pkg of 10 μg; pkg of 2 μg
• 保管条件: avoid repeated freeze/thaw cycles
• テクニック: cell culture | mammalian: suitable
• 不純物: ≤1 EU/μg
• 適合性: suitable for
• UniProtアクセッション番号: P61812
• 保管温度: −20°C
• 遺伝子情報: human ... TGFB2(7042) , TGFBR2(7048)

詳細

詳細

The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41.[1] The encoded protein is localized to extracellular matrix.[2] TGF-β2 is a member of the TGF-β superfamily.[3] TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.[4]

アプリケーション

Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells.[5] It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.[6]

生物化学的／生理学的作用

形質転換成長因子-β2（TGF-β2）は、TGF-β1と同様に、多くの細胞タイプによって産生されており、哺乳動物の血小板中が最も高濃度であると報告されています。

TGF-β2 is known to stimulate cell growth, differentiation, migration and survival.[7] TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis.[6] TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells.[8][9] TGF-β is associated with the process of tumor development, progression and metastasis.[10] TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis.[7] The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.[4]

物理的形状

凍結乾燥品(0.2 μmフィルタ-濾過済み30% アセトニトリルおよび0.1% トリフルオロ酢酸, 0.1 mg BSA含有)

アナリシスノート

生物活性は、マウスHT-2細胞に対するIL-4依存性の増殖阻害活性として測定しました。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)