T182

チルホスチンA9

solid

• 別名: [[3,5-ビス(1,1-ジメチルエチル)-4-ヒドロキシフェニル]メチレン]プロパンジニトリル, マロノベン
• 実験式（ヒル表記法）: C₁₈H₂₂N₂O
• CAS番号: 10537-47-0
• 分子量: 282.38
• MDL番号: MFCD00209853
• UNSPSCコード: 51111800
• PubChem Substance ID: 24278069
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 色: yellow
• mp: 139-140 °C
• 溶解性: ethanol: 20 mg/mL; DMSO: <25 mg/mL; H₂O: insoluble
• SMILES記法: CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C
• InChI: 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChI Key: MZOPWQKISXCCTP-UHFFFAOYSA-N
• 遺伝子情報: human ... EGFR(1956) , ORAI1(84876) , PDGFRA(5156) , PDGFRB(5159) ; mouse ... Eef2k(13631) , Prkaca(18747) , Prkca(18750) , Src(20779)

詳細

アプリケーション

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

生物化学的／生理学的作用

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

特徴および利点

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調製ノート

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301 + H311
• 注意書き: P280 - P301 + P310 + P330 - P302 + P352 + P312
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges