Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
≥90% (SDS-PAGE)
フォーム
lyophilized powder
分子量
42.9 kDa
UniProtアクセッション番号
アプリケーション
cell analysis
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
human ... MAPT(4137)
詳細
Tau-412 human, (1N4R) recombinant, is one of the isoforms of Tau and lacks a projection domain region.[1] The isoforms of tau are generated by alternate splicing. The N terminal region of tau is acidic and is separated from the C-terminal tubulin-binding region by a central proline-rich region. The isoforms differ in amino-terminal N1 and N2 regions as well as binding repeats at the tubulin region.[2] Tau belongs to the family of neuronal microtubule-associated proteins.
生物化学的／生理学的作用
タウのアイソフォ-ム、1N4Rバリアントです。4つの微小管が結合した繰り返し体(R)、およびN末端に1つの挿入断片(N)を有しています。
Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions.[1] Under pathological conditions Tau can also undergo modifications such as hyperphosphorylation, which can result in the generation of aberrant aggregates such as found in neurofibrillary tangles in Alzheimer′s disease.[2] Tau-412 human is purified without any acid treatment and is suitable for promoting microtubule assembly, and for hyperphosphorylation-induced self-assembly into filaments.
再構成
凍結乾燥品(MES, pH 6.8, NaCl, EGTA含有)。水で復元するとタンパク質濃度1 mg/mL、約50mM MESバッファ-溶液(pH 6.8, 100 mM NaCl, 0.5 mM EGTA含有)になります。
保管分類コード
11 - Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T0326-VAR:
T0326-50UG:
T0326-BULK:
T0326-50UG-PW:
Abolfazl Jangholi et al.
Archives of biochemistry and biophysics, 609, 1-19 (2016-09-18)
In many neurodegenerative diseases, formation of protein fibrillar aggregates has been observed as a major pathological change. Neurofibrillary tangles, mainly composed of fibrils formed by the microtubule-associated protein; Tau, are a hallmark of a group of neurodegenerative diseases such as
Simon Moussaud et al.
Molecular neurodegeneration, 9, 43-43 (2014-10-30)
The accumulation of α-synuclein aggregates is the hallmark of Parkinson's disease, and more generally of synucleinopathies. The accumulation of tau aggregates however is classically found in the brains of patients with dementia, and this type of neuropathological feature specifically defines
Jesus Avila et al.
Physiological reviews, 84(2), 361-384 (2004-03-27)
The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated
A Himmler et al.
Molecular and cellular biology, 9(4), 1381-1388 (1989-04-01)
Tau proteins consist of a family of proteins, heterogeneous in size, which associate with microtubules in vivo and are induced during neurite outgrowth. In humans, tau is one of the major components of the pathognomonic neurofibrillary tangles in Alzheimer's disease
M Goedert et al.
Neuron, 3(4), 519-526 (1989-10-01)
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with
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What is the Department of Transportation shipping information for this product?
1 回答-
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What is the amino acid sequence and isoelectric point of Product T0326, Tau-412 human?
1 回答-
Our supplier of Product T0326, Tau-412 human, has outline the following amino acid sequence for the protein:MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEAEEAGIG DTPSLEDEAA GHVTQARMVS KSKDGTGSDD KKAKGADGKT KIATPRGAAP PGQKGQANAT RIPAKTPPAP KTPPSSGEPP KSGDRSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV RTPPKSPSSA KSRLQTAPVP MPDLKNVKSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS KCGSKDNIKH VPGGGSVQIV YKPVDLSKVT SKCGSLGNIHHKPGGGQVEV KSEKLDFKDR VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GLThe isoelectric point is pI=8.96
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アクティブなフィルタ
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