T0202

Tocainide 塩酸塩

≥98% (HPLC), solid

• 別名: 2-Amino-N-(2,6-dimethylphenyl)propanamide 塩酸塩
• 実験式（ヒル表記法）: C₁₁H₁₆N₂O · HCl
• CAS番号: 71395-14-7
• 分子量: 228.72
• EC Number: 275-361-2
• MDL番号: MFCD00941502
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724626
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: desiccated; under inert gas
• 色: white
• 溶解性: DMSO: >20 mg/mL; H₂O: ≥5 mg/mL
• オーガナイザー: AstraZeneca
• 保管温度: 2-8°C
• SMILES記法: Cl[H].CC(N)C(=O)Nc1c(C)cccc1C
• InChI: 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
• InChI Key: AMZACPWEJDQXGW-UHFFFAOYSA-N
• 遺伝子情報: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

詳細

アプリケーション

Tocainide hydrochloride may be used in cell signaling studies.

生物化学的／生理学的作用

Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus.[1] It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.[2]

Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.

特徴および利点

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); K_i = 115 μM in blockade of inactivated-state sodium channels; IC₅₀ = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC₅₀ = 254 μM in blockade of Na+ currents at HP -70 mV; IC₅₀ = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC₅₀ = 248 μM for use-dependent block at 10 Hz.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves