SRP8058

Tim-4 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 別名: PC cell-derived growth factor, TIM4, TIMD4
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in CHO cells
• アッセイ: ≥98% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: monomer 54 kDa by calculation
• 包装: pkg of 100 μg
• 不純物: <0.06 EU/μg endotoxin, tested
• 色: white
• UniProtアクセッション番号: Q96H15
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... Timd4(276891)

詳細

詳細

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

物理的形状

Lyophilized from 0.2 μm-filtered solution in PBS.

再構成

Reconstitute at 100 μg/mL in sterile PBS.

その他情報

The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable