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由来生物
human
リコンビナント
expressed in HEK 293 cells
アッセイ
≥95% (SDS-PAGE)
形状
lyophilized
分子量
(18 and 25 kDa, monomer, glycosylated)
包装
pkg of 10 μg
テクニック
cell culture | mammalian: suitable
NCBIアクセッション番号
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
human ... IL1B(3553)
詳細
Interleukin-1β (IL1B) is produced by activated macrophages. It is synthesized as pro-IL-1β which is changed to active form IL-1β with the help of pro-inflammatory protease caspase-1. IL-1β belongs to the IL-1 gene family. It is a proinflammatory cytokine. The gene is mapped to human chromosome 2q14. In comparison with the Escherichia coli expressed protein, IL-1β is 50% more potent in promoting human CD4+ T cell differentiation into Th17 (T helper) cells. This cytokine is produced in a serum free, chemically defined media.
アプリケーション
- IL-1β (IL1B) has been used to check the expression of NGAL (neutrophil gelatinase-associated lipocalin) in epithelial cells after stimulation with proinflammatory cytokines.
- It has been used to check anti-inflammatory activities of N-Acetylglucosamine in human chondrocytes.
- It has been used to create inflammatory endothelium in human coronary artery endothelial cells.
生物化学的／生理学的作用
IL-1β (IL1B) stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation and fibroblast growth factor activity. IL-1β proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1β is present in chronic inflamed tissues and also in tissues going for fibrogenesis. It brings neutrophil and macrophage to the site of infection. Mutations in IL-1β gene are linked with renal manifestations and renal sequelae in Henoch-Schönlein purpura. It is also associated with destruction of β-cell in type 1 diabetes.
物理的形状
Lyophilized from a PBS solution.
調製ノート
バイアルは、開封前に遠心してください。
再構成
Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6169-10UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha.
Cowland JB
Journal of Immunology, 171, 6630-6639 (2003)
Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders.
Takahashi T
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 85, 135-141 (1998)
Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway.
Pirhonen J
Journal of Immunology, 162, 7322-7329 (1999)
Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms.
Zhang Y
Journal of Immunology, 161, 3071-3076 (1998)
Xiao Liu et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(9), 2391-2402 (2014-05-20)
To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory role of suppressor of cytokine signaling 3 (SOCS-3) in murine chondrocytes. In wild-type (WT) mouse chondrocytes, baseline receptor expression levels and
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