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由来生物
rat
リコンビナント
expressed in E. coli
アッセイ
≥95% (HPLC)
≥95% (SDS-PAGE)
フォーム
lyophilized
有効性
30 ng/mL
分子量
~30 kDa
包装
pkg of 10 μg
保管条件
avoid repeated freeze/thaw cycles
不純物
endotoxin, tested
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
rat ... Il17a(25465)
詳細
IL-17A (interleukin 17A) is the first cytokine member of the family composed of IL-17A-F. These cytokines are mainly produced by activated CD4+ (cluster of differentiation) T cells. IL-17A is predominantly synthesized by T-helper (Th)-17 lymphocytes, γδ T cells (γδ-17), cytotoxic CD8+ T cells (Tc17), natural killer T (NKT) cells, and neutrophils.[1][2]
生物化学的／生理学的作用
IL-17A (interleukin 17A) acts as a regulator of immune responses in inflammatory disorders, and acts as a potent pleiotropic proinflammatory cytokine where it promotes the release of other pro-inflammatory cytokines from a variety of cells. This cytokine is linked with pain, and IL-17A and IL-17A+ T cells are found in patients with arthritic pain, and in induced animal models of sciatic nerve, and optic nerve injury with neuropathic pain. This protein is thought to be involved in myocardial remodeling and fibrosis, where it promotes the synthesis of collagens and matrix metalloproteinases (MMPs) and activates cardiomyocyte apoptosis.[1][3]
Recombinant rat IL-17 produced from Escherichia coli is a homodimeric, non-glycosylated polypeptide containing 268 amino acids and has a molecular weight of 30kDa.
Recombinant rat IL-17 produced from Escherichia coli is a homodimeric, non-glycosylated polypeptide containing 268 amino acids and has a molecular weight of 30kDa.
物理的形状
凍結乾燥品(10 mMクエン酸ナトリウム, pH 3.0)。
再構成
バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。
Reconstitute in water to a concentration of 0.1-1.0 μg/μL (Note: Gently pipetting to dissolve). The solution can then be diluted into other aqueous buffers.
最新バージョンのいずれかを選択してください：
Baraa Noueihed et al.
Frontiers in cell and developmental biology, 9, 630645-630645 (2021-02-09)
Ischemic retinopathies (IRs), such as retinopathy of prematurity and diabetic retinopathy, are characterized by an initial phase of microvascular degeneration that results in retinal ischemia, followed by exaggerated pathologic neovascularization (NV). Mesenchymal stromal cells (MSCs) have potent pro-angiogenic and anti-inflammatory
Wendy Dankers et al.
Arthritis research & therapy, 20(1), 212-212 (2018-09-22)
Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeutic strategies. Chronic synovial inflammation could be suppressed by targeting RA synovial
Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery.
Maione F et al
International Journal of Inflammation, 2014, 247503-247503 (2014)
Lisa Wolf et al.
American journal of physiology. Lung cellular and molecular physiology, 311(5), L1015-L1022 (2016-10-04)
Lung epithelial cells are suggested to promote pathogen-induced pulmonary inflammation by the release of chemokines, resulting in enhanced recruitment of circulating leukocytes. Recent studies have shown that the interleukin-17C (IL-17C) regulates innate immune functions of epithelial cells in an autocrine
Pengfei Ni et al.
Journal of neuroinflammation, 15(1), 332-332 (2018-12-07)
Perioperative neurocognitive disorders (PND) occur frequently after surgery, especially in aged patients. Surgery-induced neuroinflammation and blood-brain barrier (BBB) dysfunction play a crucial role in the pathogenesis of PND. Interleukin-17A (IL-17A) increases after surgical stress and will be involved in BBB
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