おすすめの製品
品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to beige
溶解性
DMSO: 2 mg/mL, clear (Warmed)
保管温度
2-8°C
SMILES記法
[s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5
InChI
1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChI Key
JAMULYFATHSZJM-UHFFFAOYSA-N
生物化学的／生理学的作用
Potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor in vitro and in vivo.
NU7441 is a potent and selective DNA-dependent protein kinase inhibitor (DNA-PK IC50 = 14 nM; IC50 = 1.7 μM/mTOR, 5 μM/PI3Kα, >100 μM/ATM & ATR) that effectively sensitizes cancer cells to the cytotoxic effects of both ionizing radiation and the topoisomerase II inhibitor etoposide in cultures (0.5 μM; SW620 & LoVo cells) and in vivo (10 mg/kg via daily i.p. in mice with human colon cancer SW620 xenografts).
NU7441 is a potent and selective DNA-dependent protein kinase inhibitor (DNA-PK IC50 = 14 nM; IC50 = 1.7 μM/mTOR, 5 μM/PI3Kα, >100 μM/ATM & ATR) that effectively sensitizes cancer cells to the cytotoxic effects of both ionizing radiation and the topoisomerase II inhibitor etoposide in cultures (0.5 μM; SW620 & LoVo cells) and in vivo (10 mg/kg via daily i.p. in mice with human colon cancer SW620 xenografts).
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML3923-10MG:
SML3923-VAR:
SML3923-50MG:
SML3923-BULK:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated
Biochemical Pharmacology, 71(1-2), 13-20 (2005)
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
Cancer research, 66(10), 5354-5362 (2006)
Justin J J Leahy et al.
Bioorganic & medicinal chemistry letters, 14(24), 6083-6087 (2004-11-18)
A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted chromenone libraries, which were screened as inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). These studies resulted in the identification of 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one (NU7441)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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