SML2972

Cyclopentenyl uracil

≥98% (HPLC)

• 別名: 1-[(1R,4R,5S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2,4(1H,3H)-pyrimidinedione, Cyclopentenyluracil, Cyclopentenyluridine, NSC 375574
• 実験式（ヒル表記法）: C₁₀H₁₂N₂O₅
• CAS番号: 90597-20-9
• 分子量: 240.21
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: [nH]1[c]([n](cc[c]1=O)[C@H]2[C@@H]([C@@H](C(=C2)CO)O)O)=O
• InChI: 1S/C10H12N2O5/c13-4-5-3-6(9(16)8(5)15)12-2-1-7(14)11-10(12)17/h1-3,6,8-9,13,15-16H,4H2,(H,11,14,17)/t6-,8-,9+/m1/s1
• InChI Key: FCWVOJUKQSHZIV-VDAHYXPESA-N

詳細

生物化学的／生理学的作用

Cyclopentenyl uracil is a non-cytotoxic inhibitor of uridine kinase that act as a potent inhibitor of pyrimidine salvage in the intact mouse. Combination of Cyclopentenyl uracil with GSK983 significantly reduces viral infection of dengue serotype 2 (DENV-2) strain 16681 in cultures of the A549 lung carcinoma cell line. Cyclopentenyl uracil in combination with GSK983 enhances therapeutic index of viral RdRp inhibitor R1479.

non-cytotoxic inhibitor of uridine kinase that act as a potent inhibitor of pyrimidine salvage

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable