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アッセイ
≥98% (HPLC)
形状
powder
色
white to very dark brown
溶解性
DMSO: 2 mg/mL, clear (warmed)
保管温度
2-8°C
関連するカテゴリー
生物化学的／生理学的作用
CL097 is an imidazoquinoline (IMDQ) derivative (IQD) with dual toll-like receptor 7 & 8 (TLR7 & TLR8; TLR7/8) agonist activity. CL097 is commonly employed in the concentration range from 0.5 μg/mL to 45 μg/mL for stimulating cell surface TLR7/8 in cultures and is reported to be a stronger TLR7 ligand than CL075.
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML2566-BULK:
SML2566-25MG:
SML2566-5MG:
SML2566-VAR:
試験成績書（COA）
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Zhikuan Zhang et al.
Cell reports, 25(12), 3371-3381 (2018-12-20)
Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and ssRNA. However, the specific ssRNA
Jueqi Chen et al.
Nature, 564(7734), 71-76 (2018-11-30)
The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). NLRP3 is
Susanne Maria Ziegler et al.
Journal of reproductive immunology, 128, 30-37 (2018-06-11)
During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to
Masaaki Okamoto et al.
The Journal of biological chemistry, 293(48), 18585-18600 (2018-10-05)
The innate immune system is important for the efficacy of vaccines, but excessive innate immune responses can cause adverse reactions after vaccination. Extracellular vesicles (EVs) are enriched in the blood and can deliver functional RNAs, such as microRNAs (miRNAs), to
Xinqiang Hong et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 30(2), 197-208 (2018-06-05)
The aim of the present study was to investigate the effects of 5-fluorouracil (5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells (DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide (α-GC) tumor vaccine exhibits
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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