SML2004

Cangrelor tetrasodium salt

≥95% (HPLC), P2Y12 antagonist, powder

• 別名: AR-C69931 tetrasodium salt, AR-C69931MX tetrasodium salt, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P′-(dichloromethylene)bis[phosphonic acid]-5′-Adenylic acid tetrasodium salt
• 実験式（ヒル表記法）: C₁₇H₂₁Cl₂F₃N₅O₁₂P₃S₂·Na₄
• CAS番号: 163706-36-3
• 分子量: 864.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

特性

• 製品名: Cangrelor tetrasodium salt, ≥95% (HPLC)
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O[C@@H]1[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)O[C@H]1N(C=N2)C3=C2C(NCCSC)=NC(SCCC(F)(F)F)=N3
• InChI: 1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32;;;;/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32);;;;/q;4*+1/p-4/t8-,10-,11-,14-;;;;/m1..../s1
• InChI key: COWWROCHWNGJHQ-OPKBHZIBSA-J

詳細

Application

Cangrelor has been used as a purinergic receptor P2Y12 antagonist to study its effects on neuromedin U receptor 2 (NMUR2)-coupled Gαi pathway during platelet aggregation.

Biochem/physiol Actions

Cangrelor is a potent and selective platelet P2Y12 antagonist. It is used as an intravenous antiplatelet drug to prevent formation of harmful blood clots in the coronary arteries.

Potent and selective platelet P2Y12 antagonist

Cangrelor is an analog of nonthienopyridine adenosine triphosphate. It has a therapeutic effect against reversible platelet inhibition.

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable