SML1784

BTI-A-404

≥98% (HPLC)

• 別名: 4-[4-(Dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxamide
• 実験式（ヒル表記法）: C₂₂H₂₆N₄O₂
• CAS番号: 537679-57-5
• 分子量: 378.47
• UNSPSCコード: 51111800
• PubChem Substance ID: 329826063
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: O=C1NC(C2=CC=C(N(C)C)C=C2)C(C(NC3=CC(C)=CC(C)=C3)=O)=C(C)N1

詳細

生物化学的／生理学的作用

BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (GPR43/Free Fatty Acid Receptor 2, FFAR2) that increases the cyclic AMP level and regulates and reduces acetate-induced cytoplasmic Ca²⁺ level. BTI-A-404 regulates the downstream signaling pathways of GPR43, including ERK, p38 MAPK, and NF-KB. BTI-A-404 stimulates GLP-1 release.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable