SML1782

CATPB

≥98% (HPLC)

• 別名: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
• 実験式（ヒル表記法）: C₁₉H₁₇ClF₃NO₃
• CAS番号: 1322598-09-3
• 分子量: 399.79
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826062
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(N[C@@H](CC1=CC=C(C(F)(F)F)C=C1)CC(O)=O)CC2=CC=CC(Cl)=C2
• InChI Key: QOSIJVVNNGXEKE-INIZCTEOSA-N

詳細

生物化学的／生理学的作用

An acetamidophenylbutanoate derivative with inverse agonist and antagonist activity against human, but not mouse or rat, FFA2 (GPR43)

CATPB is an acetamidophenylbutanoate derivative with inverse agonist and antagonist activity against human, but not mouse or rat, FFA2 (GPR43). CATPB inhibits both constitutive and propionate (C3) -stimulated hFFA2 GTPγS incorporation (IC50 ~35 and 320 nM, respectively; [C3] = EC80, ~125 nM), as well as C3-induced hFFA2 G159E activity (IC50 ~400 nM). CATPB is shown to inhibit C3-induced intracellular ERK phosphorylation in hFFA2-expressing cells (IC50 ~3 μM against 10 mM C3).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable