SML1677

Tarocin A1

≥98% (HPLC)

• 別名: (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(3-(isoquinolin-4-yl)propanoyl)-4-methyloxazolidin-2-one
• 実験式（ヒル表記法）: C₂₄H₁₈F₆N₂O₃
• CAS番号: 2095106-05-9
• 分子量: 496.40
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826010
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: C[C@H](N1C(CCC2=C(C=CC=C3)C3=CN=C2)=O)[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OC1=O
• InChI: 1S/C24H18F6N2O3/c1-13-21(16-8-17(23(25,26)27)10-18(9-16)24(28,29)30)35-22(34)32(13)20(33)7-6-15-12-31-11-14-4-2-3-5-19(14)15/h2-5,8-13,21H,6-7H2,1H3/t13-,21-/m0/s1
• InChI Key: XWMRKUPNQVITEC-ZSEKCTLFSA-N

詳細

生物化学的／生理学的作用

Tarocin A1 is an oxazolidinone which inhibits TarO, the first enzyme in teichoic acid synthesis. Tarocin A1 has an IC₅₀ value of 40 nM in a biochemical TarO assay. Tarocin A does not inhibit bacterial growth alone, and exhibits no cytotoxicity against HeLa cells, but it has potent bactericidal syergism with broad spectrum β-lactams, and may restore the clinical efficacy of existing β-lactam antibiotics.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable