SML1654

R-Ketorolac

≥95% (HPLC)

• 別名: (+)-Ketorolac, (1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;, (R)-(+)-ketorolac, (R)-Ketorolac
• 実験式（ヒル表記法）: C₁₅H₁₃NO₃
• CAS番号: 66635-93-6
• 分子量: 255.27
• MDL番号: MFCD00871492
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825993
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 光学活性: [α]/D +162 to +178°, c = 1 in methanol
• 色: white to beige
• 溶解性: DMSO: 25 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O=C(O)[C@H]1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1
• InChI: 1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1
• InChI Key: OZWKMVRBQXNZKK-LLVKDONJSA-N

詳細

生物化学的／生理学的作用

Ketorolac ((rac)-5-benzoyl-1,2-3H-pyrrolo[1,2a] pyrrole1-carboxylic acid) is a non-steroidal anti-inflammatory drug (NSAID). It is used as a racemic mixture that contains a 1:1 ratio of the R(+) and S(−) stereoisomers. It is broadly used off-label as a parenteral analgesic in children.[1] Ketorolac serves as a non-narcotic analgesic. It prevents the synthesis of prostaglandins, peripheral to the central nervous system.[2]

R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.

R-Ketorolac is potent and selective Rho-family GTPases Cdc42 and Rac1 allosteric inhibitor.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable