SML1069

TH287 hydrochloride

≥98% (HPLC)

• 別名: 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride
• 実験式（ヒル表記法）: C₁₁H₁₀Cl₂N₄ · HCl
• CAS番号: 1609960-30-6
• 分子量: 305.59
• MDL番号: MFCD28127273
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825648
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: ClC1=CC=CC(C2=NC(N)=NC(NC)=C2)=C1Cl.Cl
• InChI: 1S/C11H10Cl2N4.ClH/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13;/h2-5H,1H3,(H3,14,15,16,17);1H
• InChI Key: YBLIJWDQSUDCJU-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

TH287 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC₅₀ value of 0.8 nM. MTH1 hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage. MTH1 removal of oxidized nucleotides that result from increased levels of reactive oxygen species (ROS) in fast-proliferating cancer cells helps protect cancer cells from proliferative stress and prevent cancer cell death. TH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.

TH287 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1).

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H318
• 注意書き: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable