SML0791

N,N-Dimethyltryptamine

≥97% (HPLC)

• 別名: DMT
• 実験式（ヒル表記法）: C₁₂H₁₆N₂
• CAS番号: 61-50-7
• 分子量: 188.27
• MDL番号: MFCD00055989
• UNSPSCコード: 12352116
• PubChem Substance ID: 329825600
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• 形状: powder
• 薬剤管理: USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
• 色: white to beige
• 溶解性: DMSO: 15 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: CN(C)CCC1=CNC2=C1C=CC=C2
• InChI: 1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
• InChI Key: DMULVCHRPCFFGV-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

N,N-Dimethyltryptamine (DMT) functions as a hallucinogen. Experimental studies states that DMT is an endogenous sigma-1 receptor agonist. DMT interacts with sigma-1 receptors and blocks voltage-gated sodium ion (Na⁺) channels in both native cardiac myocytes and heterologous cells that contain sigma-1 receptors.

N,N-Dimethyltryptamine (DMT) is a hallucinogen now known to be an endogenous sigma-1 receptor agonist. In keeping with the known sigma-1 receptor modulation of voltage gated Na+ channels, DMT was found to reversibly inhibit Na currents by 62% in vitro. N,N-Dimethyltryptamine also induced hypermotility in WT mice (but not in sigma-1 KO mice), all evidence of its sigma-1 agonist activity.

特徴および利点

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その他情報

Product contains 1.2% wt. EtOH (by NMR and EA).

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H336
• 注意書き: P261 - P271 - P304 + P340 + P312 - P403 + P233 - P405 - P501
• 危険有害性の分類: STOT SE 3
• ターゲットの組織: Central nervous system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable