SML0761

ゴッシピン

≥90% (HPLC)

• 別名: 3,3′,4′,5,7,8-ヘキサヒドロキシフラボン 8-グルコシド
• 実験式（ヒル表記法）: C₂₁H₂₀O₁₃
• CAS番号: 652-78-8
• 分子量: 480.38
• MDL番号: MFCD00017429
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825593
• NACRES: NA.77

特性

• 由来生物: Hibiscus vitifolius
• アッセイ: ≥90% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: , light yellow to dark green-yellow
• 溶解性: DMSO: 15 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
• InChI Key: SJRXVLUZMMDCNG-KKPQBLLMSA-N

詳細

詳細

Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces β-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.

生物化学的／生理学的作用

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable