The stability of this material in solution at 4°C has not been determined. Following reconstitution, aliquot and freeze at -20°C for up to 3 months.
SML0545
CID 1067700
≥98% (HPLC)
別名:
2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid, 2-[[(Benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid, CID-1067700, CID1067700, SID57578339
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5 MG
￥19,800
25 MG
￥62,800
About This Item
おすすめの製品
品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to light brown
溶解性
DMSO: 10 mg/mL, clear
保管温度
2-8°C
SMILES記法
[s]1c2c(c(c1NC(=S)NC(=O)c3ccccc3)C(=O)O)CC(OC2)(C)C
InChI
1S/C18H18N2O4S2/c1-18(2)8-11-12(9-24-18)26-15(13(11)16(22)23)20-17(25)19-14(21)10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,(H,22,23)(H2,19,20,21,25)
InChI Key
ATSWBWHRHAQVFM-UHFFFAOYSA-N
生物化学的／生理学的作用
CID 1067700 antagonizes ras-related protein Rab-7 and reduces class switch DNA recombination (CSR) in B cells and survival of plasma cells.[1]
CID 1067700 is a potent and competitive inhibitor of Ras-related GTPases that potently binds to Rab7 nucleotide binding site.
CID 1067700 is a potent and competitive inhibitor of Ras-related GTPases.
特徴および利点
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML0545-VAR:
SML0545-BULK:
SML0545-25MG:
SML0545-5MG:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
A Remedy for Lupus through Restraining Rab7
How H I V.
Journal of Immunology, 197, 3749-3750 (2016)
Shuai Li et al.
Experimental cell research, 370(1), 87-97 (2018-06-17)
Autophagy dysfunction has been observed in intervertebral disc degeneration (IVDD) cells, a main contributing factor to cell death, but the precise role of autophagy during IVDD is still controversial. This study aimed to investigate the role of autophagy involved in
Xueyu Wang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14473-14489 (2020-09-07)
O-GlcNAcylation is a form of posttranslational modification, and serves various functions, including modulation of location, stability, and activity for the modified proteins. O-linked-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential cellular enzyme that posttranslationally modifies the cellular proteins with O-GlcNAc moiety.
Lin Bai et al.
Cell death & disease, 12(4), 392-392 (2021-04-14)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by motoneuron loss, for which there is currently no effective treatment. Statins, as inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are used as drugs for treatment for a variety of disease such
Yong Lin et al.
Autophagy, 16(3), 548-561 (2019-06-18)
Glucosamine (GlcN), a dietary supplement widely utilized to promote joint health and effective in the treatment of osteoarthritis, is an effective macroautophagy/autophagy activator in vitro and in vivo. Previous studies have shown that autophagy is required for hepatitis B virus
資料
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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