SML0415

Alantolactone

≥98% (HPLC)

• 別名: (+)-Alantolactone., 3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one, Alant camphor, Elecampane camphor, Eupatal, Inula camphor, NSC 333843, NSC 93131
• 実験式（ヒル表記法）: C₁₅H₂₀O₂
• CAS番号: 546-43-0
• 分子量: 232.32
• EC Number: 208-899-3
• MDL番号: MFCD00274568
• UNSPSCコード: 51111800
• PubChem Substance ID: 329825410
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated; protect from light
• 色: white to beige
• 溶解性: DMSO: 15 mg/mL (clear solution)
• 保管温度: −20°C
• SMILES記法: C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12
• InChI: 1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1
• InChI Key: PXOYOCNNSUAQNS-AGNJHWRGSA-N

詳細

詳細

Alantolactone is a compound produced by Inula helenium.[1] Alantolactone has antibacterial, antifungal, anti-inflammatory and anticancer properties. It suppresses signal transducer and activator of transcription 3 (STAT3) activation in liver and breast cancer cells. Alantolactone induces apoptosis in A549 lung cancer cells.[2]

アプリケーション

Alantolactone has been used:

• in cell viability assay[1]
• to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)[3]
• in assessment of degranulation[4]

生物化学的／生理学的作用

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

Alantolactone is an inducer of activin/SMAD3 signaling.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable