SML0230

GW-803430

≥98% (HPLC)

• 別名: 6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one, GW-3430, GW-803430A
• 実験式（ヒル表記法）: C₂₅H₂₄ClN₃O₃S
• CAS番号: 515141-51-2
• 分子量: 481.99
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: ≥4 mg/mL at warmed to 60 °C
• オーガナイザー: GlaxoSmithKline
• 保管温度: 2-8°C
• SMILES記法: [s]1c2c(nc[n]([c]2=O)c4cc(c(cc4)OCCN5CCCC5)OC)cc1c3ccc(cc3)Cl
• InChI: 1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3
• InChI Key: MWULMTACIBZPGN-UHFFFAOYSA-N

詳細

アプリケーション

GW-803430 may be used in MCHR1-mediated cell signaling studies.

生物化学的／生理学的作用

GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice.[1] It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.[2]

GW-803430 is a centraly active and selective melanin-concentrating hormone receptor (MCHR) 1 antagonist

特徴および利点

This compound is featured on the Melanin-Concentrating Hormone Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319
• 注意書き: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable