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由来生物
rabbit
品質水準
リコンビナント
expressed in proprietary host
結合体
unconjugated
抗体製品の状態
tissue culture supernatant
抗体製品タイプ
primary antibodies
クローン
SP6, monoclonal
化学種の反応性
human (tested)
化学種の反応性（ホモロジーによる予測）
bovine
テクニック
immunohistochemistry: 1:200
アイソタイプ
IgG
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... MKI67(4288)
詳細
Ki-67 is a nuclear protein, which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.
免疫原
Synthetic peptide from C-terminus of human Ki-67 protein.
アプリケーション
Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生物化学的／生理学的作用
Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB5500134-100UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Ki67 labelling index: an independent predictor of progression in prostate cancer treated by radical prostatectomy.
Bubendrof L, et al.
The Journal of Pathology, 178(4), 437-441 (1996)
The Ki?67 protein: from the known and the unknown.
Scholzen T and Johannes G
Journal of Cellular Physiology, 182(3), 311-322 (2000)
Veronique L Veenstra et al.
Molecular oncology, 11(8), 1050-1064 (2017-05-10)
Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma
The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system.
Chaverra M, et al.
Disease models & mechanisms, 10(5), 605-618 (2017)
CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma.
Tu M, et al.
Molecular Medicine Reports, 15(4), 1713-1721 (2017)
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