Aquaporin 4 (AQP4) is expressed in the nervous system. The gene ID of the protein is 25293.
特異性
Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.
免疫原
C-terminal peptide
生物化学的/生理学的作用
Aquaporin 4 (AQP4) functions as a water channel in the rat brain.
特徴および利点
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物理的形状
PBS, pH 7..4, 50% glycerol, and 0.09% sodium azide
免責事項
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Trimethyltin chloride (TMT) is a neurotoxicant producing neuronal degeneration and reactive astrogliosis in the mammalian central nervous system, especially the hippocampus. A previous magnetic resonance imaging investigation in TMT-treated rats evidenced dilation of lateral ventricles, also suggesting alterations in blood-brain
Aquaporins (AQPs) are a family of transmembrane proteins involved in the maintenance of osmotic gradients. AQP4 is abundant in skeletal muscle, where it seems to be associated with glycolytic metabolism. We investigated the pattern of expression of AQP4 in normal
Journal of neuroinflammation, 18(1), 181-181 (2021-08-23)
Intractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of NMOSD pain remains to be elucidated. In this study, we focused on ATP, which is one of the damage-associated molecular patterns, and
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer's disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to