Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4) is one of the subunits of hyperpolarization-activated cyclic nucleotide-gated channels, which have a role in synaptic transmission, dendritic integration, membrane and action potential. It is a heteromeric channel. HCN4 is highly expressed in rat embryonic hearts, specifically in the sinoatrial node.
特異性
Detects ~130 kDa. No cross-reactivity against other HCNs
免疫原
Fusion protein amino acids 1019-1198 (c-terminus) of rat HCN4, Accession Number Q9JKA7
特徴および利点
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物理的形状
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
免責事項
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Journal of neurophysiology, 121(6), 2126-2139 (2019-04-04)
The inferior colliculus (IC) is a large midbrain nucleus that integrates inputs from many auditory brainstem and cortical structures. Despite its prominent role in auditory processing, the various cell types and their connections within the IC are not well characterized.
HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.
Hughes DI
Neuroscience (2013)
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
The Journal of physiology, 596(11), 2055-2075 (2018-03-11)
The present study demonstrates, by in vitro and in vivo analyses, the novel concept that signal transmission between sympathetic neurons and the heart, underlying the physiological regulation of cardiac function, operates in a quasi-synaptic fashion. This is a result of
Pacing and clinical electrophysiology : PACE, 42(2), 275-282 (2018-12-24)
The HCN4 gene encodes a subunit of the hyperpolarization-activated cyclic nucleotide-gated channel, type 4 that is essential for the proper generation of pacemaker potentials in the sinoatrial node. The HCN4 gene is often present in targeted genetic testing panels for
