P0749

Anti-Potassium Channel K_v11.1 Extracellular antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 別名: Anti-HERG, Anti-KCNH2
• MDL番号: MFCD02097212
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 化学種の反応性: human
• テクニック: flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 10⁶ cells); immunocytochemistry: 1:25; western blot: 1:200 using HEK-K_V11.1 transfected cells
• UniProtアクセッション番号: Q12809
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KCNH2(3757) ; mouse ... Kcnh2(16511) ; rat ... Kcnh2(117018)

詳細

詳細

The K⁺ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K⁺ channels based on the number of transmembrane domains. The voltage-gated Potassium or K_v channels belong to the 6 TM K⁺ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. K_v11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in K_v11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. K_v11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel K_v11.1 extracellular antibodies are specific to K_v11.1.

免疫原

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human K_V11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

アプリケーション

Anti-Potassium channel K_v11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of K_v11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

物理的形状

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable