SAB4700632

Monoclonal Anti-HLA Class I antibody produced in mouse

clone MEM-81, purified immunoglobulin, buffered aqueous solution

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: MEM-81, monoclonal
• フォーム: buffered aqueous solution
• 交差性: human
• 濃度: 1 mg/mL
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_002116.6; NM_002117.4; NM_005514.6
• UniProtアクセッション番号: P04439
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... HLA-A(3105) , HLA-B(3106) , HLA-C(3107)

詳細

詳細

Human leukocyte antigen A classical class I family consists of three members including HLA-A, HLA-B and HLA-C. Members of classical class I major histocompatibility complex (MHC) contain a peptide bound to a transmembrane glycoprotein subunit, the heavy chain, in association with a soluble light chain called β2-microglobulin. Class I MHC are present in changeable volumes on all nucleated cells.

The antibody MEM-81 reacts with human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.

The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.

免疫原

Leukocytes of a patient suffering with LGL type leukemia

アプリケーション

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生物化学的／生理学的作用

Human leukocyte antigen A class I downregulation is implicated in tumor invasion and development. Genetic variations in the class I major histocompatibility complex (MHC) is associated with the development of melanoma. HLA-viral peptide interaction plays a major role in the regulation of human immunodeficiency virus (HIV) infection.

特徴および利点

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物理的形状

PBS（pH 7.4、15 mM アジ化ナトリウム含有）

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable