SAB4700518

Monoclonal Anti-CD71-FITC antibody produced in mouse

clone MEM-75, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-TFRC, Anti-Transferrin Receptor
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: FITC conjugate
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: MEM-75, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_001128148.1
• UniProtアクセッション番号: P02786
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TFRC(7037)

詳細

詳細

Transferrin receptor (TFRC, p90) is also known as cluster of differentiation 71 (CD71). The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. In human chromosome, the gene TFRC is localized on 3q29.

免疫原

NALM-6 human pre-B cell line

アプリケーション

試薬は、100 μL全血または1e6細胞懸濁液につき20 μLの試薬を用いたヒト血液細胞のフローサイトメトリー解析用にデザインされています。バイアル（2 mL）の内容量は100回分です。

生物化学的／生理学的作用

Transferrin receptor (TFRC, CD71) facilitates the uptake of iron bound to transferrin (Tf) through clathrin-mediated endocytosis. TFRC interacts with iron-bound holo-transferrin at pH 7.4 and does not interact apo-transferrin. TFRC also binds with H-ferritin. Expression level of TFRC is regulated stringently by intracellular iron levels. The expression is higher in erythroblasts owing to haemoglobin synthesis. The expression is also higher in cancer cells, osteoclasts and activated lymphocytes, where iron requirement is high. Hypoxia and iron deficiency also increases TFRC expression. Recycling of Tf and TFRC is essential for the uptake of iron from the serum. Mutations in the internalization motif of TFRC leads to impaired endocytosis and consequently congenital/combined immunodeficiency. Improper palmitoylation of TFRC is connected to neurodegeneration with brain iron accumulation. Upregulation of TFRC is implicated in progression of pancreatic cancer, adult T-cell leukemia/lymphoma (ATLL), and cholangiocarcinoma.

特徴および利点

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物理的形状

PBS（15 mM アジ化ナトリウム、安定化剤として0.2％ハイグレード プロテアーゼフリーBSA含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable