The antibody MEM-262 recognizes β chains of the TCR expressed by HPB-ALL cell line [carrying V(beta5.3)] and a small subset of peripheral blood T cells. TCR β/TCRB (T cell receptor β chain) is located on human chromosome 7q34. This gene has at least 65 rearrangeable Vβ gene segments (27 Vβ families), two Dβ segments (Dβ1 and Dβ2), two clusters of Jβ gene segments (Jβ1.1–Jβ 1.6 and Jβ2.1–Jβ2.7) and two Cβ gene segments.
免疫原
Human thymoma cell line HPB-ALL
アプリケーション
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生物化学的/生理学的作用
The complementary determining region 3 (CDR3) of the TCR β/TCRB (T cell receptor β) is essential for the identification of the major histocompatibility complex (MHC)−peptide complex.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
PBS(pH 7.4、15 mM アジ化ナトリウム含有)
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)
TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse
Van der Velden, et al.
Leukemia, 18(12), 1971-1971 (2004)
The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma