SAB4504268

Anti-phospho-TAK1 (pThr¹⁸⁴) antibody produced in rabbit

affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 67 kDa
• 交差性: human, rat, mouse
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:1000; western blot: 1:500-1:1000
• NCBIアクセッション番号: O43318
• UniProtアクセッション番号: O43318
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr184)
• 遺伝子情報: human ... MAP3K7(6885)

詳細

詳細

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is encoded by MAP3K7. TAK1 is a 606-residue protein, that contains a serine-threonine/tyrosine-protein kinase catalytic domain and a C-terminal coiled-coil domain. It is a member of the mitogen-activated protein kinase kinase kinase family (MAP3K). This gene is mapped to human chromosome 6q15.

免疫原

The antiserum was produced against synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184.

Immunogen Range: 161-210

生物化学的／生理学的作用

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) participates in the mitogen-activated protein kinase (MAPK)-p38 signaling pathway. This gene also participates in the autophagy process in retinal pigment epithelial cells. Mutations in MAP3K7 result in cardiospondylocarpofacial syndrome.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable