SAB4503821

Anti-phospho-HSL (pSer^855/554) antibody produced in rabbit

affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 116 kDa
• 交差性: mouse, rat, human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBIアクセッション番号: Q05469
• UniProtアクセッション番号: Q05469
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pSer855/pSer554)
• 遺伝子情報: human ... LIPE(3991)

詳細

詳細

Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. The gene coding for a protein is mapped on human chromosome 19q13. The encoded protein is an intracellular lipase with various neutral lipid substrates, such as triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. HSL is widely expressed.

免疫原

The antiserum was produced against synthesized peptide derived from human HSL around the phosphorylation site of Ser855/554.

Immunogen Range: 520-569

生物化学的／生理学的作用

Hormone sensitive lipase (HSL) plays an important role in various processes such as lipolysis, adipocytes, steroidogenesis and spermatogenesis. Deficiency of HSL contributes to histologic abnormalities in white adipose tissue and an increase in macrophage infiltration. Polymorphism in the gene has been observed in familial lipodystrophies patients.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable