SAB4503802

Anti-phospho-BTK (pTyr⁵⁵¹) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-AGMX1, Anti-AT, Anti-ATK, Anti-BPK, Anti-IGHD3, Anti-IMD1, Anti-PSCTK1, Anti-XLA
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 76 kDa
• 交差性: rat, human, mouse
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:40000; western blot: 1:500-1:1000
• NCBIアクセッション番号: Q06187
• UniProtアクセッション番号: Q06187
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr551)
• 遺伝子情報: human ... BTK(695)

詳細

詳細

Bruton tyrosine kinase (BTK) is encoded by the gene mapped to human chromosome Xq22. The encoded protein belongs to the Tec family of kinases.

免疫原

The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551.

Immunogen Range: 516-565

生物化学的／生理学的作用

Bruton tyrosine kinase (BTK) is a key element of B-cell–receptor signaling, which facilitates interactions with the tumor microenvironment and stimulates the survival and proliferation of chronic lymphocytic leukemia (CLL) cells. The encoded protein also plays a crucial role in activation of various constitutively active pathways of CLL-cell survival, such as the Akt, extracellular signal-regulated kinase (ERK) and nuclear factor κ light-chain enhancer of activated B cells (NF-κB) pathways. Additionally, it is also necessary for chemokine-mediated homing and adhesion of B cells. Polymorphisms in the gene are associated with the development of a symptomatic primary antibody deficiency (PAD), X-linked agammaglobulinemia.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable