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由来生物
rabbit
結合体
peroxidase conjugate
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
詳細
Research area: Microbiome
フォーム
lyophilized powder
分子量
25-30 kDa
交差性
Staphylococcus aureus
濃度
~4 mg/mL
テクニック
direct ELISA: 1:2,000-1:4,000 (recommended using 1 μg/ml Staphylococcal Enterotoxin A for coating.)
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
Staphylococcus aureus ... sea(22112712)
詳細
Staphylococcus aureus is a Gram positive bacterium, that cause diseases in human population including food poisoning and toxic shock syndrome. S. aureus expresses several secreted virulence factors, such as various enzymes, cytotoxins, exotoxins, and exfoliative toxins. Exotoxins include more than 20 serologically classified staphylococcal enterotoxins (SEs), the best characterize are the SEs A, B through V and toxic shock syndrome toxin-1 (TSST-1), these enterotoxins are similar in activity, sequence, structure and molecular weight (~25-30 kDa).
Mainly SEA but also SEB are known as superantigens due to their ability to bind class II MHC molecules on antigen presenting cells and stimulate extensive T-cells activation followed by massive cytokine release leading to an acute toxic shock.
SE proteins have a significant resistance to heat and acid, it is also resistant to gastrointestinal proteases including pepsin, trypsin, rennin and papain. Thus, killing the S. aureus bacteria may not be sufficient to eliminate these superantigens risk from causing food poisoning.
As described in various researches, detection of SEA contamination is a major challenge in the food industry, including milk and cooked food products.
SEA high affinity to MHC class II receptors on antigen presenting cells and tissues, followed by the excessive systemic immune activation, was applied in attempts to use bispecific antibodies (BsAbs) genetically fused to SEA as a T-cell stimulator. The SEA activation resulted in a non-specific activation of MHC class II-positive tissues which causes side-effects. Mutated SEA, D227A was developed to reduce the adverse effects for directing activated T-cells toward tumor cells.
Mainly SEA but also SEB are known as superantigens due to their ability to bind class II MHC molecules on antigen presenting cells and stimulate extensive T-cells activation followed by massive cytokine release leading to an acute toxic shock.
SE proteins have a significant resistance to heat and acid, it is also resistant to gastrointestinal proteases including pepsin, trypsin, rennin and papain. Thus, killing the S. aureus bacteria may not be sufficient to eliminate these superantigens risk from causing food poisoning.
As described in various researches, detection of SEA contamination is a major challenge in the food industry, including milk and cooked food products.
SEA high affinity to MHC class II receptors on antigen presenting cells and tissues, followed by the excessive systemic immune activation, was applied in attempts to use bispecific antibodies (BsAbs) genetically fused to SEA as a T-cell stimulator. The SEA activation resulted in a non-specific activation of MHC class II-positive tissues which causes side-effects. Mutated SEA, D227A was developed to reduce the adverse effects for directing activated T-cells toward tumor cells.
免疫原
Purified toxin from Staphylococcus aureus, (This toxin is coded by a bacteriophage).
アプリケーション
The antibody may be used in various immunochemical techniques including ELISA.
物理的形状
Supplied as a lyophilized powder.
その他情報
In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.
免責事項
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
11 - Combustible Solids
WGK
WGK 2
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
毒物及び劇物取締法
劇物
Jan Code
SAB4200830-VAR:
SAB4200830-1VL:
SAB4200830-BULK:
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アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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