SAB4200272

Anti-Progerin antibody, Mouse monoclonal

clone 13A4, purified from hybridoma cell culture

• 別名: Anti-CDCD1, Anti-CDDC, Anti-CMD1A, Anti-CMT2B1, Anti-EMD2, Anti-FPL, Anti-FPLD, Anti-HGPS, Anti-IDC, Anti-LDP1, Anti-LFP, Anti-LMN1, Anti-LMNA, Anti-LMNC, Anti-LMNL1, Anti-Lamin A/C, Anti-PRO1, Anti-Renal carcinoma antigen NY-REN-32
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: 13A4, monoclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~70 kDa
• 化学種の反応性: human
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): suitable; indirect immunofluorescence: suitable; western blot: 2.5-5.0 μg/mL using whole extracts of HeLa cells overexpressing human progerin.
• アイソタイプ: IgG1
• UniProtアクセッション番号: P02545
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... LMNA(4000)

詳細

詳細

Monoclonal Anti-Progerin (mouse IgG1 isotype) is derived from the hybridoma 13A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. A-type lamins, lamin A and lamin C are products of a single gene, LMNA, which are produced by alternative splicing. Prelamin A, the precursor of Lamin A, is farnesylated at its carboxy terminus after synthesis and the last 18 amino acids, which contain the farnesyl group, are removed by the metalloprotease Zmpste24, producing the mature Lamin A. The LMNA gene codes for A-type lamin, lamin A/C.

アプリケーション

Monoclonal Anti-Progerin antibody produced in mouse has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

生物化学的／生理学的作用

Mutations in Lamin A have been linked to a variety of rare human diseases including muscular dystrophy, lipodystrophy, cardiomyopathy, neuropathy and progeroid syndromes (collectively termed laminopathies) and to premature aging (Hutchinson-Gilford progeria syndrome). Lamins A/C participate in maintaining nuclear integrity, modulation of gene expression, cell proliferation and apoptosis.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable