SAB2501042

抗TIP30/CC3抗体 ヤギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗HIV-1 Tat相互作用タンパク質2抗体, 抗HTATIP2抗体, 抗Tat相互作用タンパク質(30 kDa)抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 交差性: human
• テクニック: indirect ELISA: suitable; western blot: suitable
• UniProtアクセッション番号: Q9BUP3
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... HTATIP2(10553)

詳細

詳細

Tat-interacting protein 30 (TIP30), also called CC3/ HIV-1 tat interactive protein 2 (HTATIP2), is a putative tumor suppressor. It is encoded by the gene mapped to human chromosome 11p15.1. TIP30 is primarily localized in cytoplasm and it belongs to short-chain dehydrogenases/reductase (SDR) family. The encoded protein is extensively expressed in various human tissues, such as the heart, brain, lung, kidney and pancreas.

免疫原

NP_006401によるタンパク質配列のN末端に由来するペプチド(AETEALSKLREDFR-C)。

生物化学的／生理学的作用

Tat-interacting protein 30 (TIP30) has an ability to promote apoptosis and suppress metastasis and angiogenesis. It is also implicated in regulation of DNA repair and tumor cell metabolism. Down-regulated expression of the gene is associated with the development of various cancers, including melanoma, breast cancer, neuroblastoma, glioblastoma, colon cancer, lung cancer and hepatocellular carcinoma. Elevated expression of the gene in glioma cells inhibits tumor proliferation, metastasis and migration. Thus, TIP30 can be considered as a potent target for treating glioma patients.

特徴および利点

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物理的形状

Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)の0.5 mg/mL溶液。

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable