S9564

アミロイド前駆体タンパク質α, 分泌型 ヒト

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

• 別名: sAPPα
• MDL番号: MFCD03454663
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• リコンビナント: expressed in E. coli (N-terminal histidine tagged)
• 品質水準: 200
• アッセイ: >90% (SDS-PAGE)
• フォーム: buffered aqueous solution
• 分子量: ~100 kDa by SDS-PAGE
• UniProtアクセッション番号: P05067
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... APP(351)

詳細

詳細

The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3.[1] It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.[2]

アプリケーション

Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).[3][4][5]

生物化学的／生理学的作用

Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.[6]

物理的形状

PBS溶液 (pH 7.4, 0.2μmフィルタ-滅菌済み)

調製ノート

可溶性タンパク質として発現させた後、未変性の条件下で精製しています。

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable