S5944

S-15176 二フマル酸塩

≥98% (HPLC), solid

• 別名: N-[(3,5-ジ-tert-ブチル-4-ヒドロキシ-1-チオフェニル)]-3-プロピル-N'-(2,3,4-トリメトキシベンジル)ピペラジン 二フマル酸塩
• 化学式: C₃₁H₄₈N₂O₄S · 2 C₄H₄O₄
• CAS番号: 148913-55-7
• 分子量: 776.93
• MDL番号: MFCD11046049
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824557
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• 溶解性: DMSO: soluble 16 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.COc1ccc(CN2CCN(CCCSc3cc(c(O)c(c3)C(C)(C)C)C(C)(C)C)CC2)c(OC)c1OC
• InChI: 1S/C31H48N2O4S.2C4H4O4/c1-30(2,3)24-19-23(20-25(27(24)34)31(4,5)6)38-18-10-13-32-14-16-33(17-15-32)21-22-11-12-26(35-7)29(37-9)28(22)36-8;2*5-3(6)1-2-4(7)8/h11-12,19-20,34H,10,13-18,21H2,1-9H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+
• InChI Key: ANXPOPNCJIJXJW-LVEZLNDCSA-N

詳細

アプリケーション

The protonophoric activity of S-15176 difumarate salt was studied in mitochondria isolated from livers of Wistar rats.⁵

生物化学的／生理学的作用

Antioxidant and anti-ischemic agent. Also inhibits mitochondrial permeability transition, prevents the early step in apoptosis by preventing collapse of the electrochemical gradient across the mitochondrial membrane. IC₅₀ for in vitro lipid peroxidation is 0.3 μM. IC₅₀ for carnitine palmitoyltransferase (CPT-1) in heart homogenate is 16.8 μM. The shift from fatty acid to glucose oxidation may contribute to anti-ischemic effect.

S-15176 suppresses the mitochondrial permeability transition in response to calcium ions and inorganic phosphate and inhibits the release of cytochrome c in response to silver ions. It exhibits weak protonophoric activity.⁵

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves