P8615

ホスホイノシチド3-キナーゼp110γ ヒト

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

• 別名: PI3K p110γ ヒト, ホスファチジルイノシトール3-キナーゼp110γ ヒト
• MDL番号: MFCD03457993
• UNSPSCコード: 12352207
• NACRES: NA.32

特性

• リコンビナント: expressed in baculovirus infected insect cells
• 品質水準: 200
• アッセイ: ≥95% (SDS-PAGE)
• フォーム: buffered aqueous glycerol solution
• 比活性: ~4.5 units/mg protein
• UniProtアクセッション番号: P48736
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... PIK3CG(5294)

詳細

詳細

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3.[1][2] PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.[2]

生物化学的／生理学的作用

哺乳類の細胞表面受容体により引き起こされる様々な細胞応答へのPI 3-キナ-ゼの関与が示唆されています。IFN-γに誘発されるNF-κB、AP-1、STAT1α依存性の遺伝子発現を阻害し、COX-2およびNOS ll (iNOS) の発現を阻害します。

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma.[3] Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers.[4] Mutation in the gene is associated with the development of autistic disorder.[2]

単位の定義

1unitは、ホスファチジルイノシト-ルを基質とした場合、1分間あたり1nmolのリン酸を変換する活性です。

物理的形状

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable