Product No. P1038 is a single-stranded random co-polymer.
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Poly(cytidylic-inosinic) acid potassium salt has been used:
生物化学的／生理学的作用
Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).
Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC).[3] Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.[1]
その他情報
ランダムコポリマ-
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
P1038-5MG-PW:
P1038-25MG:
P1038-10MG-PW:
P1038-BULK:
P1038-VAR:
P1038-5MG:
P1038-2MG:
P1038-10MG:
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G F Joyce et al.
Journal of molecular biology, 176(2), 279-306 (1984-06-25)
Poly(C, U) random copolymer templates direct the oligomerization of 2-MeImpG and 2-MeImpA, resulting in the production of a variety of oligo/(G,A)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpA, and decreases for
G F Joyce et al.
Journal of molecular biology, 202(3), 677-681 (1988-08-05)
Poly(C,A) random copolymer templates direct the oligomerization of 2-MeImpG (2-MeImpX is the 5'-phospho-2-methylimidazolide of the nucleoside X) and 2-MeImpU, resulting in the production of a variety of oligo (G,U)s. This reaction is less efficient than comparable reactions involving poly(C,U) or
G F Joyce et al.
Journal of molecular biology, 188(3), 433-441 (1986-04-05)
Poly(C, G) random copolymer templates direct the oligomerization of 2-Me-ImpG and 2-MeImpC, resulting in the production of a variety of oligo(G, C)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpC, and decreases
Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: evidence from Manduca sexta and Blattella germanica
Garbutt JS, et al.
Journal of Insect Physiology, 59(2), 171-178 (2013)
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I: C) and murine autoimmune cholangitis
Wang J, et al.
Journal of Hepatology, 44(3), 446-454 (2006)
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Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, single or double stranded?
1 回答-
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What can I use to solubilize Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?
1 回答-
The product is soluble in water at 10 mg/mL.
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How large/long a polymer is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?
1 回答-
The average length of this polynucleotide has not been determined.
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Will Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, work to induce interferon production?
1 回答-
P1038 is a single stranded RNA. For cell activation, synthetic double-stranded RNA is widely used as the ligand of Toll-like receptor 3 (TLR3) in place of what is supposed to be the natural ligand (viral dsRNA). This would be Product No. P9582, a double stranded RNA homopolymer, i.e. Poly(I): Poly(C). This product is widely used by other satisfied customers for cell activation.
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Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, product sterile?
1 回答-
Product No. P1038 is not sterile. The product is produced in non-sterile conditions and the level of endotoxin content is not determined.
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