コンテンツへスキップ
Merck

N0258

Sigma-Aldrich

N-ニトロソジエチルアミン

ISOPAC®

別名:

ジエチルニトロソアミン

ログイン組織・契約価格を表示する

サイズを選択してください

1 G
¥24,900

¥24,900


出荷可能日2025年4月10日詳細


バルクの問い合わせ

サイズを選択してください

表示を変更する
1 G
¥24,900

About This Item

化学式:
(C2H5)2NNO
CAS番号:
分子量:
102.14
Beilstein:
1744991
EC Number:
MDL番号:
UNSPSCコード:
12352116
PubChem Substance ID:
NACRES:
NA.25

¥24,900


出荷可能日2025年4月10日詳細


バルクの問い合わせ

フォーム

liquid

bp

177 °C (lit.)

密度

0.95 g/mL (lit.)

SMILES記法

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

InChI Key

WBNQDOYYEUMPFS-UHFFFAOYSA-N

類似した製品をお探しですか? 訪問 製品比較ガイド

アプリケーション

N-ニトロソジエチルアミン(NDEA)は肝臓発癌物質/DNA障害物質として使用されています。[1][2]これは、ガス液体クロマトグラフィーの校正基準として使用されています。[3]

生物化学的/生理学的作用

N-ニトロソジエチルアミン(NDEA)は強力な肝臓癌誘発性ジアルキルニトロソアミンです。これは、主にたばこの煙、水、チェダー・チーズ、塩漬け食品、揚げた食品、および多くのアルコール飲料に含まれています。NDEAは、DNA修復/複製に関係する核酵素を変化させます。これはすべての動物種にさまざまな腫瘍を発生させます、[4]標的になる主な器官は鼻腔、気管、肺、食道、および肝臓です。

包装

シリコン/PTFE隔壁、アルミニウム引き裂きシールとともに100mL漿液ボトルに入っています。

注意

適切な溶媒を注入することで、溶液に触れずにご希望の濃度に調製していただけます。

再構成

本製品を100 mLの溶媒に溶かすことで1%の溶液が得られます。

法的情報

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPACの

製品番号
詳細
価格

ピクトグラム

Skull and crossbonesHealth hazard

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

保管分類コード

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

消防法

第4類:引火性液体
第二石油類
危険等級III
非水溶性液体

労働安全衛生法名称等を表示すべき危険物及び有害物

名称等を表示すべき危険物及び有害物

労働安全衛生法名称等を通知すべき危険物及び有害物

名称等を通知すべき危険物及び有害物

Jan Code

N0258-BULK:
N0258-1G:
N0258-VAR:


最新バージョンのいずれかを選択してください:

試験成績書(COA)

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

The detection of DNA adducts (risk factors for DNA damage). A method for genomic DNA, the results and some effects of nutritional intervention.
Howard JM
Journal of Nutritional & Environmental Medicine, 12, 19-31 (2002)
Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine.
Yuan F
Proteomics, 13, 389-389 (2013)
Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice.
Pracheta P
Asian Pacific Journal of Cancer Prevention, 12, 677-677 (2011)
Yewei Liu et al.
International journal of cancer, 143(7), 1817-1828 (2018-05-01)
To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Singh BN
Chemico-Biological Interactions, 181, 20-20 (2009)

資料

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

質問

1–7/7 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      役に立ちましたか?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか?

  3. What is the Department of Transportation shipping information for this product?

    1 回答
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      役に立ちましたか?

  4. Is Product N0258, N-nitrosoethylamine, a solid or a liquid? Why is the package size expressed in grams?

    1 回答
    1. This product is neat liquid. The package size is in grams but can be converted to volume by using the density of 0.95 g/mL.

      役に立ちましたか?

  5. What is the solubility of Product N0258, N-Nitrosodiethylamine?

    1 回答
    1. According to the chemicals encyclopedia published by the Royal Society of Chemistry, 12th edition, this compound is soluble in water, ether and alcohol.

      役に立ちましたか?

  6. How does the storage temperature relate to shipping conditions?

    1 回答
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      役に立ちましたか?

  7. How can I store solutions of Product N0258, N-Nitrosodiethylamine?

    1 回答
    1. The product should be stable in neutral solution, but it is unstable with strong acid and heat. N-nitroso amine compounds are relatively stable when dissolved in aqueous solutions at physiological pH. But they are generally light sensitive, so stock solutions should be kept cool and protected from light.

      役に立ちましたか?

レビュー

評価値なし

アクティブなフィルタ

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

製品に関するお問い合わせはこちら(テクニカルサービス)