M3319

Anti-Mint2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-Munc-18-1 Interacting Protein 2, Anti-X11β, Anti-X11L
• MDL番号: MFCD02263655
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 120 kDa
• 化学種の反応性: rat
• テクニック: immunoprecipitation (IP): 5-10 μg using a rat brain extract (S1 fraction).; microarray: suitable; western blot: 0.25-0.5 μg/mL using rat brain extract (S1 fraction)
• UniProtアクセッション番号: O35431
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... APBA2(321) ; mouse ... Apba2(11784) ; rat ... Apba2(83610)

詳細

詳細

Munc-18-1 interacting protein 2 (Mint2), also called X11L, shares 50% homology with Mint1 and both are expressed exclusively in brain and bind Munc-18-1 with high affinity. It has N-terminal Munc-18-1-interacting domain (MID), a middle phosphotyrosine-binding (PTB) domain, and two C-terminal PDZ domain. It belongs to mammalian LIN-10 protein family. Mint 2 is present in neurons.

免疫原

synthetic peptide corresponding to amino acids 1-18, located at the N-terminus of rat mint2, conjugated to KLH. This sequence is highly conserved (single amino acid substitution) in mouse mint2 and shows limited homology (66% identity) to human mint2. It does not share homology with the mint1 and mint3 isoforms.

アプリケーション

Anti-Mint2 antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunostaining

生物化学的／生理学的作用

Munc-18-1 interacting protein 2 (Mint2) participates in vesicle exocytosis. Mint 2 interacts with amyloid-β precursor protein (APP) and presenilins. It favors phosphorylation of β-amyloid precursor protein family members APP and Amyloid-like protein 2 (APLP2) in response to cellular stress, by facilitating c-Jun N-terminal kinase mediated phosphorylation.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)