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由来生物
Salmonella enterica (serotype minnesota)
品質水準
フォーム
lyophilized powder
精製方法
phenol extraction
不純物
<3% Protein (Lowry)
溶解性
water: soluble
保管温度
2-8°C
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関連するカテゴリー
詳細
リポポリサッカライド（LPS）は、グラム陰性菌の細胞壁を特徴とする構成成分です。LPSとその脂質A部分は、一般的な病原体関連分子パターン（PAMP）を認識するトール様受容体タンパク質ファミリーのメンバーであるトール様受容体4（TLR4）によって、自然免疫系の細胞を刺激します。
Lipopolysaccharide (LPS) is the pyrogenic element arising from enterobacteria such as Escherichia coli and Salmonella enterica. It is an amphiphilic component containing polysaccharides and lipoidic material. LPS is present in the outer membrane of the cell wall of almost all Gram-negative bacteria.[1]
アプリケーション
Lipopolysaccharides from Salmonella enterica serotype minnesota has been used:
- as a toll-like receptors (TLR ) agonist to induce tumor necrosis factor (TNF) α production in cereblon[2] and Rabex-5[3] deficient mice in vivo,
- to study its effect on prostaglandin-E Synthase (PTGES) protein expression in monocyte-derived macrophages[4]
- as a positive control for the maturation of monocyte-derived dendritic cells (MoDCs) to assess secretion of interleukin-10 and interferon (IFN)-γ [5]
- as a supplement in Roswell park memorial institute (RPMI)media for culturing splenic B cells [6]
- as a toll-like receptor 4 ligand to study its effect on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)[7]
生物化学的／生理学的作用
Lipopolysaccharide (LPS) forms a permeability barrier around the cell surface to restrict the entry of toxic molecules such as antibiotics and bile salts. Owing to their external location, this endotoxin also plays a vital role in host-bacterium interactions by regulating host immune response.[8] LPS is a microbe-associated molecular pattern (MAMP) that serves as a potent agonist for toll-like receptor 4 (TLR4)-MD2-CD14 receptor complex.[9]
その他情報
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
関連製品
製品番号
詳細
価格
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 2 Oral
保管分類コード
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
L6261-100MG:
I-6737:
L6261-BULK:
L6261-10MG-PW:
L6261-VAR:
L6261-10MG:
L6261-25MG:
September R Mihaly et al.
PloS one, 9(4), e94982-e94982 (2014-04-17)
Macrophages play diverse roles in tissue homeostasis and immunity, and canonically activated macrophages are critically associated with acute inflammatory responses. It is known that activated macrophages undergo cell death after transient activation in some settings, and the viability of macrophages
Shanye Yin et al.
Cancer cell, 35(2), 283-296 (2019-02-05)
SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the pathogenesis of CLL remains elusive. Here, we show that conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces
Srinivas Mamidi et al.
Immunobiology, 217(6), 593-600 (2011-12-30)
All-trans retinoic acid (ATRA) is a potent retinoid, which has been used successfully in different clinical settings as a potential drug to treat COPD and emphysema. In the present study, we analyzed genes modulated by ATRA by performing mRNA expression
Lipopolysaccharides
ACSM?s Health & Fitness Journal , 133-153 (2010)
Christiane Eder et al.
Particle and fibre toxicology, 6, 27-27 (2009-10-20)
Cytochrome P450 monoxygenases play an important role in the defence against inhaled toxic compounds and in metabolizing a wide range of xenobiotics and environmental contaminants. In ambient aerosol the ultrafine particle fraction which penetrates deeply into the lungs is considered
資料
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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