I1411
ITX3
≥98% (HPLC)
別名:
2-[(2,5-ジメチル-1-フェニル-1H-ピロール-3-イル)メチレン]-チアゾロ[3,2-a]ベンズイミダゾール-3(2H)-オン
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サイズを選択してください
5 MG
￥13,770
25 MG
￥42,250
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5 MG
￥13,770
25 MG
￥42,250
About This Item
実験式（ヒル表記法）:
C22H17N3OS
CAS番号:
分子量:
371.45
MDL番号:
UNSPSCコード:
12352202
PubChem Substance ID:
NACRES:
NA.77
おすすめの製品
アッセイ
≥98% (HPLC)
フォーム
powder
溶解性
DMSO: ≥4 mg/mL
保管温度
room temp
SMILES記法
Cc1cc(\C=C2\Sc3nc4ccccc4n3C2=O)c(C)n1-c5ccccc5
InChI
1S/C22H17N3OS/c1-14-12-16(15(2)24(14)17-8-4-3-5-9-17)13-20-21(26)25-19-11-7-6-10-18(19)23-22(25)27-20/h3-13H,1-2H3/b20-13+
InChI Key
SJMYMKPBODEZSH-DEDYPNTBSA-N
生物化学的／生理学的作用
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.
ITX3 is a specific inhibitor of endogenous TrioN activity; selective cell active inhibitor of the Trio/RhoG/Rac1 pathway.
特徴および利点
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
I1411-5MG:
I1411-25MG:
I1411-VAR:
I1411-BULK:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Kiran A Vaidya et al.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 58, 107414-107414 (2022-01-26)
Calcific aortic valve disease (CAVD), a major cause for surgical aortic valve replacement, currently lacks available pharmacological treatments. Cadherin-11 (Cad11), a promising therapeutic target, promotes aortic valve calcification in vivo, but direct Cad11 inhibition in clinical trials has been unsuccessful.
J-W Jang et al.
Oncogene, 36(7), 999-1011 (2016-07-19)
The tumor-suppressor RUNX3 has a critical role in a lineage determination, cell cycle arrest and apoptosis. Lozenge (Lz), a Drosophila homolog of mammalian RUNX family members, has integral roles in these processes and specifically in eye cell fate determination. To
Jos Van Rijssel et al.
Biology open, 2(6), 569-579 (2013-06-22)
Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleton, but are also implicated in gene regulation. However, in
Tao Tao et al.
Journal of genetics and genomics = Yi chuan xue bao, 46(2), 87-96 (2019-03-10)
As a critical guanine nucleotide exchange factor (GEF) regulating neurite outgrowth, Trio coordinates multiple processes of cytoskeletal dynamics through activating Rac1, Cdc42 and RhoA small GTPases by two GEF domains, but the in vivo roles of these GEF domains and corresponding
JinSeok Park et al.
Nature communications, 10(1), 2797-2797 (2019-06-28)
Collective cell migration occurs in many patho-physiological states, including wound healing and invasive cancer growth. The integrity of the expanding epithelial sheets depends on extracellular cues, including cell-cell and cell-matrix interactions. We show that the nano-scale topography of the extracellular
資料
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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